18-Oxocortisol Measurement in Adrenal Vein Sampling as a Biomarker for Subclassifying Primary Aldosteronism
Author(s) -
Yasuhiro Nakamura,
Fumitoshi Satoh,
Ryo Morimoto,
Masataka Kudo,
Kei Takase,
Celso E. Gómez-Sánchez,
Seijiro Honma,
Mitsunobu Okuyama,
Kouwa Yamashita,
William E. Rainey,
Hironobu Sasano,
Sadayoshi Ito
Publication year - 2011
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2010-2785
Subject(s) - primary aldosteronism , aldosterone , hyperaldosteronism , biomarker , medicine , aldosterone synthase , endocrinology , adenoma , adrenal gland , chemistry , blood pressure , renin–angiotensin system , biochemistry
18-Oxocortisol (18-oxoF) is a derivative of cortisol (F) that is produced by aldosterone synthase (CYP11B2). The potential for this steroid as a biomarker for differentiating patients with aldosterone-producing adenoma (APA) from those with idiopathic hyperaldosteronism (IHA) has not been examined.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom