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18-Oxocortisol Measurement in Adrenal Vein Sampling as a Biomarker for Subclassifying Primary Aldosteronism
Author(s) -
Yasuhiro Nakamura,
Fumitoshi Satoh,
Ryo Morimoto,
Masataka Kudo,
Kei Takase,
Celso E. Gómez-Sánchez,
Seijiro Honma,
Mitsunobu Okuyama,
Kouwa Yamashita,
William E. Rainey,
Hironobu Sasano,
Sadayoshi Ito
Publication year - 2011
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2010-2785
Subject(s) - primary aldosteronism , aldosterone , hyperaldosteronism , biomarker , medicine , aldosterone synthase , endocrinology , adenoma , adrenal gland , chemistry , blood pressure , renin–angiotensin system , biochemistry
18-Oxocortisol (18-oxoF) is a derivative of cortisol (F) that is produced by aldosterone synthase (CYP11B2). The potential for this steroid as a biomarker for differentiating patients with aldosterone-producing adenoma (APA) from those with idiopathic hyperaldosteronism (IHA) has not been examined.

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