Lower Uncarboxylated Osteocalcin Concentrations in Children with Prediabetes Is Associated with β-Cell Function
Author(s) -
Norman K. Pollock,
Paul J. Bernard,
Barbara A. Gower,
Caren M. Gundberg,
Karl Wenger,
Sudipta Misra,
Reda Bassali,
Catherine L. Davis
Publication year - 2011
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2010-2731
Subject(s) - medicine , endocrinology , osteocalcin , prediabetes , adipose tissue , impaired glucose tolerance , insulin resistance , insulin , diabetes mellitus , chemistry , type 2 diabetes , alkaline phosphatase , enzyme , biochemistry
Although animal studies suggest that it is the uncarboxylated rather than carboxylated form of osteocalcin that affects glucose homeostasis, the human data are scant and equivocal.
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