Open AccessMammalian Target of Rapamycin Pathway Activation Is Associated to RET Mutation Status in Medullary Thyroid Carcinoma
Author(s) -
Ida Rapa,
Enrico Saggiorato,
Daniela Giachino,
N Palestini,
Fabio Orlandi,
Mauro Papotti,
Marco Volante
Publication year - 2011
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2010-2655
Subject(s) - thyroid carcinoma , cancer research , medullary cavity , mutation , medicine , oncology , biology , endocrinology , thyroid , genetics , gene
The genetic pathways involved in medullary thyroid carcinomas (MTC), except for RET mutations, are largely unknown, as is the detailed mapping of proteins activated as a consequence of RET tyrosine kinase phosphorylation.
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