The Effect of Gonadotropin Withdrawal and Stimulation with Human Chorionic Gonadotropin on Intratesticular Androstenedione and DHEA in Normal Men | Zendy

Mara Y. Roth | Zendy; S. T. Page | Zendy; Kelvin Lin | Zendy; Bradley D. Anawalt | Zendy; Alvin M. Matsumoto | Zendy; Brett T. Marck | Zendy; W. J. Bremner | Zendy; John K. Amory | Zendy

Open Access

The Effect of Gonadotropin Withdrawal and Stimulation with Human Chorionic Gonadotropin on Intratesticular Androstenedione and DHEA in Normal Men

Author(s) -

Mara Y. Roth,

S. T. Page,

Kelvin Lin,

Bradley D. Anawalt,

Alvin M. Matsumoto,

Brett T. Marck,

W. J. Bremner,

John K. Amory

Publication year - 2011

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2010-2518

Subject(s) - human chorionic gonadotropin , endocrinology , medicine , androstenedione , dehydroepiandrosterone , gonadotropin , stimulation , testosterone (patch) , chemistry , androgen , hormone

Concentrations of intratesticular (IT) testosterone (T) are known to be 100-200 times those of serum T; however, the IT concentrations of T's precursors, their testicular to serum gradients, gonadotropin dependence, and response to stimulation with human chorionic gonadotropin (hCG) have not been studied in detail. We hypothesized that serum and IT androstenedione (ADD) and IT dehydroepiandrosterone (DHEA) would be significantly suppressed by the administration of a GnRH antagonist and increased when stimulated by hCG, without a similar suppression of serum DHEA.

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