Open AccessA High-Fat Diet Elicits Differential Responses in Genes Coordinating Oxidative Metabolism in Skeletal Muscle of Lean and Obese Individuals
Author(s) -
Kristen E. Boyle,
J. P. Canham,
Leslie A. Consitt,
Donghai Zheng,
Timothy R. Koves,
Timothy P. Gavin,
Donald Holbert,
P. Darrell Neufer,
Olga Ilkayeva,
Deborah M. Muoio,
Joseph A. Houmard
Publication year - 2011
Publication title -
the journal of clinical endocrinology and metabolism/journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2010-2253
Subject(s) - endocrinology , medicine , skeletal muscle , lean body mass , lipid metabolism , lipid oxidation , biology , obesity , beta oxidation , chemistry , metabolism , biochemistry , antioxidant , body weight
In lean individuals, increasing dietary lipid can elicit an increase in whole body lipid oxidation; however, with obesity the capacity to respond to changes in substrate availability appears to be compromised.