Up-Regulation of PPAR-γ mRNA Expression in the Liver of Obese Patients: an Additional Reinforcing Lipogenic Mechanism to SREBP-1c Induction | Zendy

Paulina Pettinelli | Zendy; Luis A. Videla | Zendy

Open Access

Up-Regulation of PPAR-γ mRNA Expression in the Liver of Obese Patients: an Additional Reinforcing Lipogenic Mechanism to SREBP-1c Induction

Author(s) -

Paulina Pettinelli,

Luis A. Videla

Publication year - 2011

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2010-2129

Subject(s) - medicine , endocrinology , adiponectin , steatosis , nonalcoholic fatty liver disease , insulin resistance , fatty liver , triglyceride , steatohepatitis , peroxisome proliferator activated receptor , biology , insulin , receptor , cholesterol , disease

Triglyceride accumulation in the liver is an early feature in the development of nonalcoholic fatty liver disease (NAFLD) associated with human obesity, which is a multifactorial syndrome and whose underlying mechanisms are beginning to be understood.

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