Assessment of Leydig and Sertoli Cell Functions in Infants with Nonmosaic Klinefelter Syndrome: Insulin-Like Peptide 3 Levels Are Normal and Positively Correlated with LH Levels | Zendy

Sylvie Cabrol | Zendy; Judith L. Ross | Zendy; Ilene Fennoy | Zendy; Claire Bouvattier | Zendy; Marc Roger | Zendy; Najiba Lahlou | Zendy

Open Access

Assessment of Leydig and Sertoli Cell Functions in Infants with Nonmosaic Klinefelter Syndrome: Insulin-Like Peptide 3 Levels Are Normal and Positively Correlated with LH Levels

Author(s) -

Sylvie Cabrol,

Judith L. Ross,

Ilene Fennoy,

Claire Bouvattier,

Marc Roger,

Najiba Lahlou

Publication year - 2011

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2010-2103

Subject(s) - endocrinology , medicine , klinefelter syndrome , testosterone (patch) , anti müllerian hormone , sertoli cell , follicle stimulating hormone , leydig cell , biology , hormone , infertility , luteinizing hormone , spermatogenesis , pregnancy , genetics

Klinefelter syndrome (KS) is the most common sex chromosome disorder and a major cause of male infertility. In adult patients, serum inhibin B and anti-Mullerian-hormone (AMH) are undetectable, testosterone secretion is often impaired, and the tubules are depleted of germ cells. Before puberty, inhibin B, AMH, and testosterone levels are within the normal range.

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