Preadipocyte Factor-1 Is Associated with Metabolic Profile in Severe Obesity | Zendy

Jean O’Connell | Zendy; Lydia Lynch | Zendy; Andrew E. Hogan | Zendy; Tom Cawood | Zendy; Donal O’Shea | Zendy

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Preadipocyte Factor-1 Is Associated with Metabolic Profile in Severe Obesity

Author(s) -

Jean O’Connell,

Lydia Lynch,

Andrew E. Hogan,

Tom Cawood,

Donal O’Shea

Publication year - 2011

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2010-2026

Subject(s) - adipocyte , adipose tissue , context (archaeology) , obesity , dysfunctional family , endocrinology , pathological , medicine , adipogenesis , biology , clinical psychology , paleontology

Dysfunctional adipose tissue has been proposed as a key pathological process linking obesity and metabolic disease. Preadipocyte factor-1 (Pref-1) has been shown to inhibit differentiation in adipocyte precursor cells and could thereby play a role in determining adipocyte size, adipose tissue functioning, and metabolic profile in obese individuals.

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