Twenty-Four-Hour Profiles of Acylated and Total Ghrelin: Relationship with Glucose Levels and Impact of Time of Day and Sleep | Zendy

Karine Spiegel | Zendy; Esra Tasali | Zendy; Rachel Leproult | Zendy; Neal H. Scherberg | Zendy; Eve Van Cauter | Zendy

Open Access

Twenty-Four-Hour Profiles of Acylated and Total Ghrelin: Relationship with Glucose Levels and Impact of Time of Day and Sleep

Author(s) -

Karine Spiegel,

Esra Tasali,

Rachel Leproult,

Neal H. Scherberg,

Eve Van Cauter

Publication year - 2010

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2010-1978

Subject(s) - postprandial , ghrelin , endocrinology , medicine , orexigenic , circadian rhythm , insulin , sleep (system call) , chemistry , hormone , neuropeptide , receptor , neuropeptide y receptor , computer science , operating system

The acylation of ghrelin is essential for its stimulatory effects on GH release and appetite. Most of the physiology of ghrelin has been defined based on the assay of total ghrelin (TG), which mainly reflects levels of unacylated ghrelin. Whether levels of acylated ghrelin (AG) are influenced by circadian time and sleep and impact glucose regulation under physiologic conditions is not known.

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