β-Adrenergic Receptor Blockade Does Not Inhibit Cold-Induced Thermogenesis in Humans: Possible Involvement of Brown Adipose Tissue | Zendy

S. Wijers | Zendy; Patrick Schrauwen | Zendy; Marleen A. van Baak | Zendy; Wim H. M. Saris | Zendy; Wouter D. van Marken Lichtenbelt | Zendy

Open Access

β-Adrenergic Receptor Blockade Does Not Inhibit Cold-Induced Thermogenesis in Humans: Possible Involvement of Brown Adipose Tissue

Author(s) -

S. Wijers,

Patrick Schrauwen,

Marleen A. van Baak,

Wim H. M. Saris,

Wouter D. van Marken Lichtenbelt

Publication year - 2011

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2010-1957

Subject(s) - brown adipose tissue , thermogenesis , blockade , endocrinology , adipose tissue , medicine , adrenergic , adrenergic receptor , receptor , thermogenin , biology , chemistry

Recently, brown adipose tissue (BAT) gained interest as a possible target for cold-induced thermogenesis, and therefore a target for treatment of obesity in adult humans. However, mitochondrial uncoupling takes place not only in BAT but also in skeletal muscle tissue. Both tissues may be involved in cold-induced thermogenesis, which is presumably regulated by the sympathetic nervous system.

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