Wnt/β-Catenin Pathway Activation in Adrenocortical Adenomas Is Frequently due to Somatic CTNNB1-Activating Mutations, Which Are Associated with Larger and Nonsecreting Tumors: A Study in Cortisol-Secreting and -Nonsecreting Tumors | Zendy

S. Bonnet | Zendy; Sébastien Gaujoux | Zendy; Pierre Launay | Zendy; Camille Baudry | Zendy; Ilham Chokri | Zendy; Bruno Ragazzon | Zendy; Rossella Libé | Zendy; Fernande René-Corail | Zendy; Anne Audebourg | Zendy; MarieCécile VacherLavenu | Zendy; Lionel Groussin | Zendy; Xavier Bertagna | Zendy; B. Dousset | Zendy; Jérôme Bertherat | Zendy; Frédérique Tissier | Zendy

Open Access

Wnt/β-Catenin Pathway Activation in Adrenocortical Adenomas Is Frequently due to Somatic CTNNB1-Activating Mutations, Which Are Associated with Larger and Nonsecreting Tumors: A Study in Cortisol-Secreting and -Nonsecreting Tumors

Author(s) -

S. Bonnet,

Sébastien Gaujoux,

Pierre Launay,

Camille Baudry,

Ilham Chokri,

Bruno Ragazzon,

Rossella Libé,

Fernande René-Corail,

Anne Audebourg,

MarieCécile VacherLavenu,

Lionel Groussin,

Xavier Bertagna,

B. Dousset,

Jérôme Bertherat,

Frédérique Tissier

Publication year - 2010

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2010-1885

Subject(s) - immunohistochemistry , wnt signaling pathway , catenin , pathology , staining , cancer research , biology , medicine , gene , genetics

Abnormal β-catenin immunohistochemistry and mutations of the β-catenin gene (CTNNB1) have been reported in adrenocortical adenomas (ACAs), but the frequencies of these defects and the phenotype of such tumors have not been clearly determined.

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