The Human Aldose Reductase AKR1B1 Qualifies as the Primary Prostaglandin F Synthase in the Endometrium | Zendy

Eva Bresson | Zendy; Sofia Boucher-Kovalik | Zendy; Pierre Chapdelaine | Zendy; Éric Madore | Zendy; Nathalie Harvey | Zendy; Philippe Y. Laberge | Zendy; Mathieu Lebœuf | Zendy; Michel A. Fortier | Zendy

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The Human Aldose Reductase AKR1B1 Qualifies as the Primary Prostaglandin F Synthase in the Endometrium

Author(s) -

Eva Bresson,

Sofia Boucher-Kovalik,

Pierre Chapdelaine,

Éric Madore,

Nathalie Harvey,

Philippe Y. Laberge,

Mathieu Lebœuf,

Michel A. Fortier

Publication year - 2010

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2010-1589

Subject(s) - endocrinology , endometrium , medicine , context (archaeology) , aldose reductase , menstrual cycle , prostaglandin d2 , prostaglandin , biology , diabetes mellitus , hormone , paleontology

Prostaglandins (PGs) E2 and PGF2α are produced in the endometrium and are important for menstruation and fertility. Dysmenorrhea is associated with increased production of PGF2α relative to PGE2, and the opposite is true for menorrhagia. The pathways leading to PGE2 biosynthesis are well described, but little is known for PGF2α. Aldoketoreductase (AKR)-1C3, the only PGF synthase identified in the human, cannot explain the production of PGF2α by endometrial cells. AKR1B1 appears to be an alternate candidate with promising therapeutic value.

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