Open AccessCord Blood Vitamin D Status Impacts Innate Immune Responses
Author(s) -
Valencia P. Walker,
Xiaoran Zhang,
Ida Rastegar,
Philip T. Liu,
Bruce W. Hollis,
John S. Adams,
Robert L. Modlin
Publication year - 2011
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2010-1559
Subject(s) - cathelicidin , cord blood , tlr2 , medicine , vitamin d and neurology , immune system , monocyte , vitamin , endocrinology , whole blood , antimicrobial , immunology , innate immune system , biology , microbiology and biotechnology
Our objectives were to 1) assess cord blood vitamin D concentrations from healthy term newborns, 2) ascertain whether cord blood vitamin D insufficiency precludes optimal induction of the Toll-like receptor (TLR) antimicrobial pathway in monocytes, and 3) determine whether in vitro supplementation with 25-hydroxyvitamin D(3) [25(OH)D(3)] and/or 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] restores TLR-induced antimicrobial responses.
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