Surfactant Protein-A (SP-A) Selectively Inhibits Prostaglandin F2α (PGF2α) Production in Term Decidua: Implications for the Onset of Labor
Author(s) -
Victoria Snegovskikh,
Vineet Bhandari,
Jo Rae Wright,
Serkalem Tadesse,
Thomas Morgan,
Colin MacNeill,
Nastaran Foyouzi,
Joong Shin Park,
Yuguang Wang,
Errol R. Norwitz
Publication year - 2011
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2010-1496
Subject(s) - decidua , endocrinology , medicine , decidual cells , stromal cell , myometrium , endometrium , biology , placenta , monocyte , prostaglandin , trophoblast , andrology , uterus , fetus , pregnancy , genetics
Labor is characterized by "decidual activation" with production of inflammatory mediators. Recent data suggest that surfactant protein-A (SP-A) may be critical to the onset of labor in mice. Whether this is also true in humans is unclear.
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