Open AccessTNF-α Antagonism with Etanercept Decreases Glucose and Increases the Proportion of High Molecular Weight Adiponectin in Obese Subjects with Features of the Metabolic Syndrome
Author(s) -
Takara Stanley,
Markella V. Zanni,
Stine Johnsen,
Sarah Rasheed,
Hideo Makimura,
Hang Lee,
Victor K. Khor,
Rexford S. Ahima,
Steven Grinspoon
Publication year - 2011
Publication title -
the journal of clinical endocrinology and metabolism/journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2010-1170
Subject(s) - adiponectin , medicine , endocrinology , adipokine , insulin resistance , glucose homeostasis , etanercept , metabolic syndrome , adipose tissue , insulin , tumor necrosis factor alpha , diabetes mellitus
Obesity is associated with activation of the TNF-α system, increased inflammatory markers, and insulin resistance. Although studies in rodents suggest that attenuation of TNF activity improves glucose homeostasis, the effect of prolonged inhibition of TNF-α with etanercept on inflammation and glucose homeostasis in a human model of obesity is not known.