Open AccessAbrogation of TLR4 and CD14 Expression and Signaling in Human Adrenocortical Tumors
Author(s) -
Waldemar Kanczkowski,
Piotr Tymoszuk,
Monika EhrhartBornstein,
Manfred P. Wirth,
Kai Zacharowski,
Stefan R. Bornstein
Publication year - 2010
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2010-1100
Subject(s) - biology , tlr4 , signal transduction , adrenal cortex , cancer research , adrenocortical adenoma , protein kinase b , innate immune system , endocrinology , microbiology and biotechnology , medicine , immune system , adenoma , immunology , genetics
Adrenocortical carcinoma (ACC) is a rare tumor with poor prognosis. The expression of innate immunity receptor Toll-like receptor 4 (TLR4) was recently reported in various human tumors, and TLR4 was shown to regulate tumor immune escape processes, proliferation, and resistance to chemotherapeutical agents.
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