Cerebrospinal Fluid Corticosteroid Levels and Cortisol Metabolism in Patients with Idiopathic Intracranial Hypertension: A Link between 11β-HSD1 and Intracranial Pressure Regulation? | Zendy

Alexandra J. Sinclair | Zendy; Elizabeth A. Walker | Zendy; Michael Burdon | Zendy; André P. van Beek | Zendy; Ido P. Kema | Zendy; Beverly Hughes | Zendy; Philip I. Murray | Zendy; Peter Nightingale | Zendy; Paul M. Stewart | Zendy; Saaeha Rauz | Zendy; Jeremy Tomlinson | Zendy

Open Access

Cerebrospinal Fluid Corticosteroid Levels and Cortisol Metabolism in Patients with Idiopathic Intracranial Hypertension: A Link between 11β-HSD1 and Intracranial Pressure Regulation?

Author(s) -

Alexandra J. Sinclair,

Elizabeth A. Walker,

Michael Burdon,

André P. van Beek,

Ido P. Kema,

Beverly Hughes,

Philip I. Murray,

Peter Nightingale,

Paul M. Stewart,

Saaeha Rauz,

Jeremy Tomlinson

Publication year - 2010

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2010-0729

Subject(s) - medicine , cerebrospinal fluid , endocrinology , cortisone , weight loss , glucocorticoid , intracranial pressure , 11β hydroxysteroid dehydrogenase type 1 , urine , obesity , chemistry , surgery , dehydrogenase , enzyme , biochemistry

The etiology of idiopathic intracranial hypertension (IIH) is unknown. We hypothesized that obesity and elevated intracranial pressure may be linked through increased 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) activity.

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