Open AccessDown-Regulation of Wee1 Kinase by a Specific Subset of microRNA in Human Sporadic Pituitary Adenomas
Author(s) -
Henriett Butz,
István Likó,
Sándor Czirják,
Péter Igaz,
Mohammed Munayem Khan,
Vladimir Živković,
Katalin Bálint,
Márta Korbonits,
Kàroly Rácz,
Attila Patócs
Publication year - 2010
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2010-0581
Subject(s) - wee1 , biology , microrna , pituitary tumors , cancer research , cell cycle , microbiology and biotechnology , cell , gene , endocrinology , genetics , cyclin dependent kinase 1
The tumorigenic mechanisms involved in pituitary adenomas, especially of nonfunctional pituitary adenomas (NFAs), remains unclear. Various cell cycle inhibitors have been found to be underexpressed in pituitary tumors; however, Wee1 kinase, a nuclear protein that delays mitosis and was recently recognized as a tumor suppressor gene, has not been previously investigated in pituitary tumors.
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