Growth Differentiation Factor 9 Reverses Activin A Suppression of Steroidogenic Acute Regulatory Protein Expression and Progesterone Production in Human Granulosa-Lutein Cells | Zendy

Feng-Tao Shi | Zendy; Anthony P. Cheung | Zendy; Christian Klausen | Zendy; Hefeng Huang | Zendy; Peter C. K. Leung | Zendy

Open Access

Growth Differentiation Factor 9 Reverses Activin A Suppression of Steroidogenic Acute Regulatory Protein Expression and Progesterone Production in Human Granulosa-Lutein Cells

Author(s) -

Feng-Tao Shi,

Anthony P. Cheung,

Christian Klausen,

Hefeng Huang,

Peter C. K. Leung

Publication year - 2010

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2010-0477

Subject(s) - steroidogenic acute regulatory protein , medicine , endocrinology , cholesterol side chain cleavage enzyme , granulosa cell , transfection , biology , small interfering rna , chemistry , cell culture , messenger rna , ovary , cytochrome p450 , metabolism , gene , biochemistry , genetics

We have reported that growth differentiation factor 9 (GDF9) can enhance activin A (β(A)β(A))-induced inhibin B (αβ(B)) secretion in human granulosa-lutein (hGL) cells, but its effects on steroidogenic acute regulatory protein (StAR), ovarian steroidogenic enzymes, and progesterone production are unknown. We undertook this study to further evaluate GDF9 in this regard.

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