Open AccessGlucocorticoids Turn Over Slowly in Human Adipose Tissuein Vivo
Author(s) -
Katherine A. Hughes,
Rebecca M. Reynolds,
Ruth Andrew,
Hilary Critchley,
Brian R. Walker
Publication year - 2010
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2010-0384
Subject(s) - adipose tissue , context (archaeology) , in vivo , endocrinology , medicine , intracellular , biology , microbiology and biotechnology , paleontology
Lipophilic plasma glucocorticoids are thought to gain rapid access to intracellular compartments in adipose tissue. In other organs, transport can be regulated in a steroid- and tissue-specific manner. Moreover, 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) generates additional cortisol within adipose.
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