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In humans, IGF-I and -II have an important role in pre- and postnatal growth. The IGFs circulate in plasma principally as a ternary complex with the IGF binding protein-3 and an acid-labile subunit (ALS), which increases their half life.

Acid-Labile Subunit (ALS) Gene Expression and Protein Content in Human Placentas: Differences According to Birth Weight