Vitamin D-Binding Protein Directs Monocyte Responses to 25-Hydroxy- and 1,25-Dihydroxyvitamin D | Zendy

Rene F. Chun | Zendy; Anna Lis Lauridsen | Zendy; Lizabeth Suon | Zendy; Lee A. Zella | Zendy; J. Wesley Pike | Zendy; Robert L. Modlin | Zendy; Adrian R. Martineau | Zendy; Robert J. Wilkinson | Zendy; John S. Adams | Zendy; Martin Hewison | Zendy

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Vitamin D-Binding Protein Directs Monocyte Responses to 25-Hydroxy- and 1,25-Dihydroxyvitamin D

Author(s) -

Rene F. Chun,

Anna Lis Lauridsen,

Lizabeth Suon,

Lee A. Zella,

J. Wesley Pike,

Robert L. Modlin,

Adrian R. Martineau,

Robert J. Wilkinson,

John S. Adams,

Martin Hewison

Publication year - 2010

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2010-0195

Subject(s) - cathelicidin , monocyte , vitamin d and neurology , intracrine , chemistry , vitamin d binding protein , vitamin , biochemistry , antimicrobial peptides , biology , endocrinology , immunology , receptor , peptide , paracrine signalling

Serum 25-hydroxyvitamin D (25OHD) is a key factor in determining monocyte induction of the antimicrobial protein cathelicidin, which requires intracrine conversion of 25OHD to 1,25-dihydroxyvitamin D [1,25(OH)(2)D]. Both vitamin D metabolites circulate bound to vitamin D-binding protein (DBP), but the effect of this on induction of monocyte cathelicidin remains unclear.

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