Lower Brain-Derived Neurotrophic Factor in Patients with Prader-Willi Syndrome Compared to Obese and Lean Control Subjects | Zendy

Joan C. Han | Zendy; Michael J. Muehlbauer | Zendy; Huaxia Cui | Zendy; Christopher B. Newgard | Zendy; Andrea M. Haqq | Zendy

Open Access

Lower Brain-Derived Neurotrophic Factor in Patients with Prader-Willi Syndrome Compared to Obese and Lean Control Subjects

Author(s) -

Joan C. Han,

Michael J. Muehlbauer,

Huaxia Cui,

Christopher B. Newgard,

Andrea M. Haqq

Publication year - 2010

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2010-0127

Subject(s) - haploinsufficiency , leptin , endocrinology , medicine , neurotrophic factors , context (archaeology) , brain derived neurotrophic factor , melanocortin , adipokine , obesity , psychology , hormone , biology , phenotype , paleontology , biochemistry , receptor , gene

Brain-derived neurotrophic factor (BDNF) haploinsufficiency is associated with hyperphagia and obesity in both animals and humans. BDNF appears to function downstream of the leptin-melanocortin signaling pathway to control energy balance. The potential role of BDNF in the etiology of the severe hyperphagia associated with PWS has not been previously explored.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research