The Ratio of Parathyroid Hormone as Measured by Third- and Second-Generation Assays as a Marker for Parathyroid Carcinoma | Zendy

Étienne Cavalier | Zendy; Adrian Daly | Zendy; Daniela Betea | Zendy; Pamela Nicoleta Pruteanu-Apetrii | Zendy; Pierre Delanaye | Zendy; Phil Stubbs | Zendy; A.R. Bradwell | Zendy; Jean-Paul Chapelle | Zendy; Albert Beckers | Zendy

Open Access

The Ratio of Parathyroid Hormone as Measured by Third- and Second-Generation Assays as a Marker for Parathyroid Carcinoma

Author(s) -

Étienne Cavalier,

Adrian Daly,

Daniela Betea,

Pamela Nicoleta Pruteanu-Apetrii,

Pierre Delanaye,

Phil Stubbs,

A.R. Bradwell,

Jean-Paul Chapelle,

Albert Beckers

Publication year - 2010

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2009-2791

Subject(s) - third generation , medicine , tertiary referral centre , tertiary hyperparathyroidism , urology , parathyroid carcinoma , parathyroid hormone , primary hyperparathyroidism , transplantation , first generation , adenoma , dialysis , gastroenterology , endocrinology , calcium , secondary hyperparathyroidism , telecommunications , computer science , population , environmental health

Parathyroid carcinoma (PCa) is a rare disease that can be difficult to differentiate initially from severe benign parathyroid adenoma. PCa oversecrete the amino form of PTH, which is recognized by third-generation but not by second-generation PTH immunoassays. In normal individuals, the third-generation to second-generation PTH ratio should be less than 1.

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