Open AccessThe Role of the Polycystic Ovary Syndrome Susceptibility Locus D19S884 Allele 8 in Maternal Glycemia and Fetal Size
Author(s) -
Christine M. Ackerman,
Lynn P. Lowe,
H. Lee,
F. Chen,
Edward G. Hughes,
P. Cholod,
Alan Dyer,
M. Geoffrey Hayes,
Boyd E. Metzger,
William L. Lowe,
Margrit Urbanek
Publication year - 2010
Publication title -
the journal of clinical endocrinology and metabolism/journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2009-2718
Subject(s) - offspring , polycystic ovary , insulin resistance , medicine , endocrinology , pregnancy , metabolic syndrome , fetus , population , diabetes mellitus , physiology , biology , genetics , environmental health
The high incidence of insulin resistance, type 2 diabetes, and metabolic syndrome in Western societies and their impact on quality of life emphasize the importance of identifying underlying susceptibility loci for metabolic diseases. The polycystic ovary syndrome (PCOS) susceptibility locus D19S884 allele 8 (A8) is associated with measures of insulin resistance, beta-cell dysfunction, and other metabolic phenotypes in PCOS families. We now investigate the role of D19S884 A8 in pregnancy.