Open AccessTestosterone Stimulates Adipose Tissue 11β-Hydroxysteroid Dehydrogenase Type 1 Expression in a Depot-Specific Manner in Children
Author(s) -
Lijun Zhu,
Miao Hou,
Bin Sun,
Jonas Burén,
Li Zhang,
Jun Ho Yi,
Olle Hernell,
Xiaonan Li
Publication year - 2010
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2009-2708
Subject(s) - adipose tissue , medicine , endocrinology , testosterone (patch) , 11β hydroxysteroid dehydrogenase type 1 , hormone , biology , chemistry , dehydrogenase , enzyme , biochemistry
Activation of the enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) in adipose tissue results in the production of excess tissue glucocorticoids and the induction of adiposity and visceral obesity in particular. Androgens may affect body fat distribution by regulating the local metabolism of cortisol.
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