Open AccessAngiotensin II Enhances Insulin-Stimulated Whole-Body Glucose Disposal but Impairs Insulin-Induced Capillary Recruitment in Healthy Volunteers
Author(s) -
Amy M. Jonk,
Alfons J.H.M. Houben,
Nicolaas C. Schaper,
Peter W. de Leeuw,
Erik H. Serné,
Yvo M. Smulders,
Coen D.A. Stehouwer
Publication year - 2010
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2009-2587
Subject(s) - insulin , medicine , endocrinology , angiotensin ii , context (archaeology) , glucose uptake , chemistry , biology , receptor , paleontology
Angiotensin II (AngII) increases insulin-mediated glucose uptake in healthy individuals. The underlying mechanisms are undefined. AngII may increase glucose uptake through a direct effect on muscle cell insulin signaling or through increasing insulin delivery to muscle cells through effects on the microvasculature.
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