Open AccessDissimilar Hepatotoxicity Profiles of Propylthiouracil and Methimazole in Children
Author(s) -
Scott A. Rivkees,
Ana Szarfman
Publication year - 2010
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2009-2546
Subject(s) - propylthiouracil , antithyroid agent , medicine , adverse effect , methimazole , confidence interval , adverse event reporting system , cholestasis , endocrinology , drug , gastroenterology , graves' disease , pharmacology , thyroid
The antithyroid drugs propylthiouracil and methimazole were introduced for clinical use about 60 yr ago and are estimated to be used in more than 6000 children and adolescents per year in the United States. Over the years that these medications have been used, reports of adverse events involving hepatotoxicity have appeared. To date, there has not been a systematic and comparative evaluation of the adverse events associated with antithyroid drug use.
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