Open AccessA Significant Decline in IGF-I May Predispose Young Africans to Subsequent Cardiometabolic Vulnerability
Author(s) -
Aletta E. Schutte,
Hugo W. Huisman,
Johannes M. Van Rooyen,
Leoné Malan,
Nico T. Malan,
C.M.T. Fourie,
Roan Louw,
Francois H. van der Westhuizen,
Rudolph Schutte
Publication year - 2010
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2009-2329
Subject(s) - medicine , endocrinology , pulse wave velocity , blood pressure , quartile , diabetes mellitus , confidence interval
Low serum IGF-I is an independent risk factor for diabetes and cardiovascular disease. These noncommunicable diseases are extremely common in urban black South Africans, but their IGF-I concentration is unknown. We aimed to compare serum IGF-I concentrations of African and Caucasian people, investigate their age-related IGF-I decline, and determine whether IGF-I could account, at least in part, for the high prevalence of noncommunicable diseases in black Africans.
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