Sympathetic Function in Human Carriers of Melanocortin-4 Receptor Gene Mutations | Zendy

Friedhelm Sayk | Zendy; Dennis Heutling | Zendy; Christoph Dodt | Zendy; K. Alexander Iwen | Zendy; J. Peter Wellhoner | Zendy; Susann Scherag | Zendy; Anke Hinney | Zendy; Johannes Hebebrand | Zendy; Hendrik Lehnert | Zendy

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Sympathetic Function in Human Carriers of Melanocortin-4 Receptor Gene Mutations

Author(s) -

Friedhelm Sayk,

Dennis Heutling,

Christoph Dodt,

K. Alexander Iwen,

J. Peter Wellhoner,

Susann Scherag,

Anke Hinney,

Johannes Hebebrand,

Hendrik Lehnert

Publication year - 2010

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2009-2297

Subject(s) - medicine , endocrinology , sympathetic nervous system , blood pressure , body mass index , melanocortin 4 receptor , melanocortin , microneurography , context (archaeology) , leptin , obesity , heart rate , baroreflex , biology , receptor , paleontology

Melanocortinergic pathways clearly appear to be involved in obesity-associated sympathetic overactivity and its hemodynamic and thermoregulatory consequences. Individuals with dysfunctional mutations in the melanocortin-4 receptor gene (MC4R) are subject to obesity without developing hypertension.

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