Open AccessAutoimmunity in Patients with Resistance to Thyroid Hormone
Author(s) -
Marla S. Barkoff,
Masha Kocherginsky,
João Anselmo,
Roy E. Weiss,
Samuel Refetoff
Publication year - 2010
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2009-2179
Subject(s) - autoimmunity , hormone , thyroid , medicine , immunology , immune system
Resistance to thyroid hormone (RTH) is an inherited syndrome most often caused by thyroid hormone receptor beta (TRbeta) gene mutations. Given that autoimmune thyroid disease (AITD) is prevalent in the general population, its coexistence with RTH has been presumed coincidental. It was recently proposed that chronic TSH stimulation in RTH may induce an autoimmune response, thereby increasing the chance of their coexistence.
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