Open AccessMelatonin Sensitizes Human Myometrial Cells to Oxytocin in a Protein Kinase Cα/Extracellular-Signal Regulated Kinase-Dependent Manner
Author(s) -
James T. Sharkey,
Casey Cable,
James Olcese
Publication year - 2010
Publication title -
the journal of clinical endocrinology and metabolism/journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2009-2137
Subject(s) - protein kinase c , phospholipase c , endocrinology , medicine , caldesmon , myosin light chain kinase , signal transduction , biology , diacylglycerol kinase , kinase , protein kinase a , microbiology and biotechnology , phosphorylation , calcium , calmodulin
Studies have shown that labor occurs primarily in the night/morning hours. Recently, we identified the human myometrium as a target for melatonin (MEL), the neuroendocrine output signal coding for circadian night.