Open AccessSteroidogenic Factor 1 Overexpression and Gene Amplification Are More Frequent in Adrenocortical Tumors from Children than from Adults
Author(s) -
Madson Q. Almeida,
Iberê Cauduro Soares,
T.C. Ribeiro,
Maria Candida Barisson Villares Fragoso,
Lidiane Vieira Marins,
Alda Wakamatsu,
Rodrigo Albergaria Réssio,
Mirian Yumie Nishi,
Alexander A.L. Jorge,
Antônio Marcondes Lerário,
Venâncio Avancini Ferreira Alves,
Berenice B. Mendonça,
Ana Cláudia Latronico
Publication year - 2010
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2009-2040
Subject(s) - adrenocortical carcinoma , adrenal cortex , steroidogenic factor 1 , adrenocortical adenoma , biology , tissue microarray , multiplex ligation dependent probe amplification , pathology , gene duplication , immunohistochemistry , gene , cancer research , microbiology and biotechnology , endocrinology , medicine , genetics , exon , transcription factor , nuclear receptor , adenoma
Steroidogenic factor 1 (SF-1) is a key determinant of endocrine development and function of adrenal cortex. SF-1 overexpression and gene amplification were previously demonstrated in a small group of pediatric adrenocortical tumors.
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