A Novel Ultrapressure Liquid Chromatography Tandem Mass Spectrometry Method for the Simultaneous Determination of Androstenedione, Testosterone, and Dihydrotestosterone in Pediatric Blood Samples: Age- and Sex-Specific Reference Data | Zendy

Alexandra Kulle | Zendy; Felix G. Riepe | Zendy; D. Melchior | Zendy; Olaf Hiort | Zendy; PaulMartin Holterhus | Zendy

Open Access

A Novel Ultrapressure Liquid Chromatography Tandem Mass Spectrometry Method for the Simultaneous Determination of Androstenedione, Testosterone, and Dihydrotestosterone in Pediatric Blood Samples: Age- and Sex-Specific Reference Data

Author(s) -

Alexandra Kulle,

Felix G. Riepe,

D. Melchior,

Olaf Hiort,

PaulMartin Holterhus

Publication year - 2010

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2009-1670

Subject(s) - androstenedione , dihydrotestosterone , medicine , endocrinology , testosterone (patch) , liquid chromatography–mass spectrometry , tandem mass spectrometry , androgen , chemistry , context (archaeology) , population , chromatography , mass spectrometry , hormone , biology , environmental health , paleontology

Current immunoassays for analysis of plasma androgens in children have several limitations due to antibody-specific variations of data and normal ranges. Mass spectrometry-based methods are available for individual steroids but need complex sample preparation and report only fragmentary reference data for the pediatric population.

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