Open AccessMitochondrial Function and Insulin Resistance in Overweight and Normal-Weight Children
Author(s) -
Amy Fleischman,
Matthew Kron,
David M. Systrom,
Mirko I. Hrovat,
Steven Grinspoon
Publication year - 2009
Publication title -
the journal of clinical endocrinology and metabolism/journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2009-1590
Subject(s) - insulin resistance , medicine , endocrinology , overweight , insulin , phosphocreatine , type 2 diabetes , skeletal muscle , diabetes mellitus , obesity , biology , energy metabolism
Obesity has become an epidemic in children, associated with an increase in insulin resistance and metabolic dysfunction. Mitochondrial function is known to be an important determinant of glucose metabolism in adults. However, little is known about the relationship between mitochondrial function and obesity, insulin resistance, energy expenditure, and pubertal development in children.