Open AccessAssociation of Polymorphism in the Receptor for Advanced Glycation End Products (RAGE) Gene with Circulating RAGE Levels
Author(s) -
Katrien H.J. Gaens,
Isabel Ferreira,
Carla Kallen,
Marleen M. J. van Greevenbroek,
Ellen E. Blaak,
Edith J. M. Feskens,
Joost Dekker,
Giel Nijpels,
Robert J. Heine,
Leen M. ‘t Hart,
Philip G. de Groot,
Coen D.A. Stehouwer,
Casper G. Schalkwijk
Publication year - 2009
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2009-1067
Subject(s) - glycation , single nucleotide polymorphism , medicine , endocrinology , genotype , rage (emotion) , receptor , diabetes mellitus , carbohydrate metabolism , biology , gene , genetics , neuroscience
The receptor for advanced glycation end products (RAGE)-ligand interaction has been linked to vascular complications. The family of soluble forms of RAGE (sRAGE) consists of splice variants and proteolytically cleaved and shed forms of RAGE. sRAGE may be a reflection of cell-bound RAGE. Because genetic variation in the RAGE gene may be associated with individual differences in sRAGE concentration and outcome, we investigated whether RAGE single-nucleotide polymorphisms (SNPs) were associated with circulating levels of sRAGE.
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