The Role of Insulin-Like Growth Factor (IGF) Binding Protein-2 in the Insulin-Mediated Decrease in IGF-I Bioactivity | Zendy

Ayman M. Arafat | Zendy; Martin O. Weickert | Zendy; Jan Frystyk | Zendy; Joachim Spranger | Zendy; Christof Schöfl | Zendy; Matthias Möhlig | Zendy; A. Pfeiffer | Zendy

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The Role of Insulin-Like Growth Factor (IGF) Binding Protein-2 in the Insulin-Mediated Decrease in IGF-I Bioactivity

Author(s) -

Ayman M. Arafat,

Martin O. Weickert,

Jan Frystyk,

Joachim Spranger,

Christof Schöfl,

Matthias Möhlig,

A. Pfeiffer

Publication year - 2009

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2009-0875

Subject(s) - endocrinology , medicine , insulin , insulin resistance , context (archaeology) , glucose clamp technique , pancreatic hormone , impaired glucose tolerance , glucose tolerance test , body mass index , insulin like growth factor binding protein , insulin like growth factor , growth factor , biology , receptor , paleontology

Insulin interacts with the GH-IGF system by a reciprocal regulation of IGF-binding proteins (IGFBP) and GH, which in turn regulate insulin sensitivity via bioactive IGF-I. This network is linked to metabolic syndrome and cardiovascular diseases.

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