The Role of 11ß-Hydroxysteroid Dehydrogenase 1 in Adipogenesis in Thyroid-Associated Ophthalmopathy | Zendy

Jeremy Tomlinson | Zendy; Omar M. Durrani | Zendy; Iwona Bujalska | Zendy; Laura Gathercole | Zendy; Paul J. Tomlins | Zendy; Tristan T. Q. Reuser | Zendy; Geoffrey E. Rose | Zendy; John Curnow | Zendy; Paul M. Stewart | Zendy; Elizabeth A. Walker | Zendy; Saaeha Rauz | Zendy

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The Role of 11ß-Hydroxysteroid Dehydrogenase 1 in Adipogenesis in Thyroid-Associated Ophthalmopathy

Author(s) -

Jeremy Tomlinson,

Omar M. Durrani,

Iwona Bujalska,

Laura Gathercole,

Paul J. Tomlins,

Tristan T. Q. Reuser,

Geoffrey E. Rose,

John Curnow,

Paul M. Stewart,

Elizabeth A. Walker,

Saaeha Rauz

Publication year - 2009

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2009-0873

Subject(s) - medicine , endocrinology , glucocorticoid , adipogenesis , stromal cell , adipose tissue , glucocorticoid receptor , inflammation , proinflammatory cytokine , dehydrogenase , adipocyte , biology , chemistry , enzyme , biochemistry

Thyroid-associated ophthalmopathy (TAO) is a sight-threatening autoimmune disease in which de novo adipogenesis has been identified as a fundamental pathogenic mechanism. 11beta-Hydroxysteroid dehydrogenase 1 (11beta-HSD1) increases cortisol bioavailability and is pivotal in mediating glucocorticoid responses in adipose tissue and inflammation.

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