Associations between Common Genetic Polymorphisms in Angiopoietin-Like Proteins 3 and 4 and Lipid Metabolism and Adiposity in European Adolescents and Adults
Author(s) -
Vanessa Legry,
Szilvia Bokor,
Dominique Cottel,
Laurent Béghin,
Giovina Catasta,
Enikő Nagy,
Marcela GonzálezGross,
André Spinneker,
Peter Stehle,
Dénes Molnár,
Luís A. Moreno,
Philippe Amouyel,
Jean Dallongeville,
Aline Meirhaeghe
Publication year - 2009
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2009-0769
Subject(s) - angptl4 , endocrinology , medicine , lipid metabolism , biology , minor allele frequency , apolipoprotein b , allele , population , cholesterol , genetics , allele frequency , gene , environmental health
Plasma-borne angiopoietin-like proteins (ANGPTL) act as endocrine factors on their target tissues. Because ANGPTL3 and ANGPTL4 play important roles in lipid metabolism and the regulation of adiposity in mice, we hypothesized that genetic variability at the ANGPTL3 and ANGPTL4 genes loci might influence lipid metabolism and fat deposition in humans.
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