Open AccessBioactive Insulin-Like Growth Factor-I in Obesity
Author(s) -
Jan Frystyk,
Danielle J. Brick,
Anu V. Gerweck,
Andrea L. Utz,
Karen K. Miller
Publication year - 2009
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2009-0614
Subject(s) - endocrinology , medicine , context (archaeology) , insulin like growth factor , obesity , insulin , receptor , growth factor , biological activity , chemistry , insulin like growth factor binding protein , biology , in vitro , biochemistry , paleontology
In obesity, total IGF-I is not reduced to the degree predicted by low GH levels, and free IGF-I levels are normal to high. Total and free IGF-I may not reflect IGF-I biological activity because immunoassays cannot account for the modifying effects of IGF binding proteins on interactions between IGF-I and its receptor.
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