Diagnostic Accuracy of Chromogranin A and Calcitonin Precursors Measurements for the Discrimination of Ectopic ACTH Secretion from Cushing’s Disease | Zendy

Marina Zemskova | Zendy; Eric Nylén | Zendy; Nicholas J. Patronas | Zendy; Edward H. Oldfield | Zendy; Kenneth L. Becker | Zendy; Lynnette K. Nieman | Zendy

Open Access

Diagnostic Accuracy of Chromogranin A and Calcitonin Precursors Measurements for the Discrimination of Ectopic ACTH Secretion from Cushing’s Disease

Author(s) -

Marina Zemskova,

Eric Nylén,

Nicholas J. Patronas,

Edward H. Oldfield,

Kenneth L. Becker,

Lynnette K. Nieman

Publication year - 2009

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2009-0604

Subject(s) - chromogranin a , procalcitonin , calcitonin , medicine , cushing's disease , magnetic resonance imaging , occult , gastroenterology , pathology , endocrinology , disease , immunohistochemistry , radiology , sepsis , alternative medicine

Inferior petrosal sinus sampling (IPSS) best discriminates between the two causes of ACTH-dependent Cushing's syndrome, Cushing's disease (CD) and ectopic ACTH secretion (EAS). However, when sampling is not available, adjunctive diagnostic tests might be helpful. Neuroendocrine tumors may secrete chromogranin A (CgA), calcitonin (CT), procalcitonin (ProCT), a fragment of the amino terminus of procalcitonin (NProCT), and/or ACTH.

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