Partial Primary Deficiency of Insulin-Like Growth Factor (IGF)-I Activity Associated withIGF1Mutation Demonstrates Its Critical Role in Growth and Brain Development | Zendy

Irène Netchine | Zendy; Salah Azzi | Zendy; Muriel Houang | Zendy; Danielle Seurin | Zendy; Laurence Périn | Zendy; JeanMarc Ricort | Zendy; Claudine Daubas | Zendy; Christine Legay | Zendy; Ján Mešter | Zendy; R. Herich | Zendy; François Godeau | Zendy; Yves Le Bouc | Zendy

Open Access

Partial Primary Deficiency of Insulin-Like Growth Factor (IGF)-I Activity Associated withIGF1Mutation Demonstrates Its Critical Role in Growth and Brain Development

Author(s) -

Irène Netchine,

Salah Azzi,

Muriel Houang,

Danielle Seurin,

Laurence Périn,

JeanMarc Ricort,

Claudine Daubas,

Christine Legay,

Ján Mešter,

R. Herich,

François Godeau,

Yves Le Bouc

Publication year - 2009

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2009-0452

Subject(s) - endocrinology , medicine , missense mutation , growth factor , biology , insulin like growth factor 2 , mutation , insulin like growth factor , somatomedin , microcephaly , receptor , gene , genetics

IGF-I is essential for fetal and postnatal development. Only three IGF1 defects leading to dramatic loss of binding to its type 1 receptor, IGF-1R, have been reported.

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