Open AccessProtection against Loss of Innate Defenses in Adulthood by Low Advanced Glycation End Products (AGE) Intake: Role of the Antiinflammatory AGE Receptor-1
Author(s) -
Helen Vlassara,
Weiping Cai,
Susan Goodman,
Renata Pyzik,
Angie Yong,
Chunyu Xue,
Li Zhu,
Tieade,
Michal Schnaider Beeri,
Jeremy M. Silverman,
Luigi Ferrucci,
Laurie Tansman,
Gary E. Striker,
Jaime Uribarri
Publication year - 2009
Publication title -
the journal of clinical endocrinology and metabolism/journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2009-0089
Subject(s) - medicine , glycation , kidney disease , context (archaeology) , young adult , peripheral blood mononuclear cell , inflammation , physiology , endocrinology , receptor , biology , biochemistry , in vitro , paleontology
Increased oxidant stress and inflammation (OS/infl) are linked to both aging-related diseases and advanced glycation end products (AGEs). Whereas AGE receptor-1 (AGER1) reduces OS/infl in animals, this has not been assessed in normal humans.