Polymorphisms of the Scavenger Receptor Class B Member 1 Are Associated with Insulin Resistance with Evidence of Gene by Sex Interaction | Zendy

Jeanette McCarthy | Zendy; Aleefia Somji | Zendy; Lauren A. Weiss | Zendy; Brian Steffy | Zendy; Raquel González de Vega | Zendy; Elizabeth BarrettConnor | Zendy; Gregory A. Talavera | Zendy; Richard Glynne | Zendy

Open Access

Polymorphisms of the Scavenger Receptor Class B Member 1 Are Associated with Insulin Resistance with Evidence of Gene by Sex Interaction

Author(s) -

Jeanette McCarthy,

Aleefia Somji,

Lauren A. Weiss,

Brian Steffy,

Raquel González de Vega,

Elizabeth BarrettConnor,

Gregory A. Talavera,

Richard Glynne

Publication year - 2009

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2008-2800

Subject(s) - genetics , gene , insulin resistance , biology , type 2 diabetes , scavenger receptor , heritability , candidate gene , chromosome , diabetes mellitus , endocrinology , cholesterol , lipoprotein

Genetic variation in diabetes-associated genes cumulatively explain little of the overall heritability of this trait. We sought to determine whether polymorphisms of the scavenger receptor class B, member I (SCARB1), an estrogen-regulated chromosome 12q24 positional candidate diabetes gene, were associated with type 2 diabetes or insulin resistance in a sex-specific fashion.

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