Open AccessAssociation between Serum Insulin-Like Growth Factor (IGF) I and IGF Binding Protein-3 and Lung Function
Author(s) -
Sven Gläser,
Nele Friedrich,
Ralf Ewert,
Christoph Schäper,
Matthias Nauck,
Marcus Dörr,
Henry Völzke,
Stephan B. Felix,
Alexander Krebs,
Henri Wallaschofski,
Beate Koch
Publication year - 2009
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2008-2662
Subject(s) - medicine , endocrinology , anabolism , vital capacity , acromegaly , body mass index , lung volumes , insulin like growth factor , lung , pulmonary function testing , insulin like growth factor binding protein , respiratory system , population , growth factor , lung function , hormone , growth hormone , receptor , diffusing capacity , environmental health
There is strong evidence that IGF-I and IGF binding protein 3 (IGFBP-3), as central mediators of endocrine and finally metabolic or anabolic effects of GH, were associated with increased lung size in acromegaly or a decrease of respiratory muscle pressures in patients with GH deficiency. The aim of the present study was to further clarify the impact of IGF-I and IGFBP-3 levels on lung volumes and respiratory pressures in a general adult population.
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