Open AccessDifferential Effects of ChlorthalidoneVersusSpironolactone on Muscle Sympathetic Nerve Activity in Hypertensive Patients
Author(s) -
Dileep V. Me,
Debbie Arbique,
Zhongyun Wang,
Beverley AdamsHuet,
Richard J. Auchus,
Wanpen Vongpatanasin
Publication year - 2009
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2008-2660
Subject(s) - chlorthalidone , spironolactone , diuretic , medicine , baroreflex , endocrinology , context (archaeology) , essential hypertension , insulin resistance , blood pressure , insulin , heart rate , heart failure , biology , paleontology
Previous studies in rats indicated that thiazide-type diuretics reduced blood pressure (BP) and triggered baroreflex-mediated increase in sympathetic nerve activity (SNA), whereas spironolactone exerted central sympathoinhibitory action in addition to diuretic effects.
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