Open AccessPentosidine and Increased Fracture Risk in Older Adults with Type 2 Diabetes
Author(s) -
Ann V. Schwartz,
Patrick Garnero,
Teresa A. Hillier,
Deborah E. Sellmeyer,
Elsa S. Strotmeyer,
Kenneth R. Feingold,
Helaine E. Resnick,
Frances A. Tylavsky,
Dennis M. Black,
Steven R. Cummings,
Tamara B. Harris,
Douglas C. Bauer
Publication year - 2009
Publication title -
the journal of clinical endocrinology and metabolism/journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2008-2498
Subject(s) - pentosidine , medicine , diabetes mellitus , hazard ratio , odds ratio , bone mineral , confidence interval , endocrinology , type 2 diabetes , albuminuria , incidence (geometry) , cohort study , bone density , osteoporosis , glycation , physics , optics
Type 2 diabetes is associated with higher fracture risk at a given bone mineral density. Advanced glycation endproducts (AGEs) accumulate in bone collagen with age and diabetes and may weaken bone.