Correlation of Telomere Length and Telomerase Activity with Occult Ovarian Insufficiency | Zendy

Samantha Butts | Zendy; Harold Riethman | Zendy; Sarah J. Ratcliffe | Zendy; Alka Shaunik | Zendy; Christos Coutifaris | Zendy; Kurt T. Barnhart | Zendy

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Correlation of Telomere Length and Telomerase Activity with Occult Ovarian Insufficiency

Author(s) -

Samantha Butts,

Harold Riethman,

Sarah J. Ratcliffe,

Alka Shaunik,

Christos Coutifaris,

Kurt T. Barnhart

Publication year - 2009

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2008-2269

Subject(s) - telomerase , premature ovarian insufficiency , infertility , occult , medicine , telomere , ovarian reserve , premature ovarian failure , endocrinology , granulosa cell , biology , ovary , pregnancy , pathology , genetics , gene , alternative medicine

Occult ovarian insufficiency is associated with infertility, impaired response to ovarian stimulation, and reduced live birth rates in women treated with assisted reproductive technologies. Although a decline in ovarian follicle number is expected with age, the proximate causes of occult ovarian insufficiency in young women remain poorly understood. Abnormalities in telomere length and telomerase activity in human granulosa cells may serve as molecular markers for this condition.

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