Increased Production of 17β-Estradiol in Endometriosis Lesions Is the Result of Impaired Metabolism | Zendy

Bert Delvoux | Zendy; Patrick G. Groothuis | Zendy; Thomas D’Hooghe | Zendy; Cleophas Kyama | Zendy; Gerard A.J. Dunselman | Zendy; Andrea Romano | Zendy

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Increased Production of 17β-Estradiol in Endometriosis Lesions Is the Result of Impaired Metabolism

Author(s) -

Bert Delvoux,

Patrick G. Groothuis,

Thomas D’Hooghe,

Cleophas Kyama,

Gerard A.J. Dunselman,

Andrea Romano

Publication year - 2008

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2008-2218

Subject(s) - endometriosis , endocrinology , aromatase , medicine , estrogen , estrone , endometrium , ectopic expression , chemistry , gene , cancer , biochemistry , breast cancer

substantial evidence suggests that the expression of steroid metabolizing enzymes in endometriosis is altered, turning the ectopic endometrium into a source of 17beta-estradiol. However, whether these differences result in a net increase in local 17beta-estradiol production/activity has not been shown.

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