Hyperglycemia Acutely Lowers the Postprandial Excursions of Glucagon-Like Peptide-1 and Gastric Inhibitory Polypeptide in Humans | Zendy

Kirsten Vollmer | Zendy; Husai Gardiwal | Zendy; Bjoern A. Menge | Zendy; Oliver Goetze | Zendy; Carolyn F. Deacon | Zendy; Wolfgang E. Schmidt | Zendy; Jens J. Holst | Zendy; Juris J. Meier | Zendy

Open Access

Hyperglycemia Acutely Lowers the Postprandial Excursions of Glucagon-Like Peptide-1 and Gastric Inhibitory Polypeptide in Humans

Author(s) -

Kirsten Vollmer,

Husai Gardiwal,

Bjoern A. Menge,

Oliver Goetze,

Carolyn F. Deacon,

Wolfgang E. Schmidt,

Jens J. Holst,

Juris J. Meier

Publication year - 2009

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2008-2197

Subject(s) - postprandial , incretin , medicine , endocrinology , gastric inhibitory polypeptide , gastric emptying , glucagon like peptide 1 , type 2 diabetes , inhibitory postsynaptic potential , glucagon , gastrointestinal hormone , diabetes mellitus , peptide hormone , stomach , insulin , hormone

Impaired secretion of glucagon-like peptide 1 (GLP-1) has been suggested to contribute to the deficient incretin effect in patients with type 2 diabetes. It is unclear whether this is a primary defect or a consequence of the hyperglycemia in type 2 diabetes. We examined whether acute hyperglycemia reduces the postprandial excursions of gastric inhibitory polypeptide (GIP) and GLP-1, and if so, whether this can be attributed to changes in gastric emptying.

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